|Medusa Creant (Master)
Now go to the Altar 3 (just off of room 2-16). Use your bones and summon the Copper Draco; kill him and get the eye. Then go to Altar 4 (just off of room 2-10) and summon the Golem to get the next eye. Next go to Altar 2 (just off of 3-16) and kill the Fire Drake; kill and receive your third eye. Finally go to Altar 1 (just off of 3-10), this Dragon has three heads and gives you an eye for each head killed. Pick up the three eyes and return to the nobis weaponsmith to have him put them in you Talisman to create a Full Talisman. Also be sure to get a Giant Pearl from Lynith Beach and pay the weaponsmith to put it into the Talisman to get the Summoning Talisman.
After all that, go to Altar 5 (just off of Oren Ruins 3-2). Use the Summoning Talisman to summon the Medusa; kill it whichever way you can and it will drop a Medusa Tail. Pick it up and return to the Altar to claim your prize.